Tramadol And Serotonin Syndrome Facts
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Tramadol And Serotonin Syndrome Facts in Answers
Serotonin Syndrome, zoloft + tramadol? I take zoloft nightly and tramadol during the day. About 6 hours apart from each other at the least. I heard about serotonin syndrome and I had never even heard about from my doc who prescribed both drugs. Is the risk from taking both at the same time or taking them at all together in the same day? I am on 50 mg of zoloft and 400 of tramadol for a broken shoulder.

John de Witt replied: "The risk is there, and both drugs have pretty well reached a steady state in your bloodstream after taking them regularly for a few days, so the times you take them aren't very much germaine. But the risks are also so low that I fully understand why your doctor wouldn't have bothered to mention the risk."

Could this dose of tramadol result in serotonin syndrome? I recently took 100mg of tramadol, as prescribed by a physician. After about an hour, I suffered severe drowsiness, dizziness, some nausea, and a bad headache. I've slept off most of the symptoms, but the sense of heavy mental fuzziness remains. It's been present for about two days. I also have mono, which I know can result in mental fatigue, but I'm wondering if I may have serotonin syndrome on top of that as a result of the tramadol reaction. I don't know if 100mg is enough to trigger the syndrome, however. Thanks!

R. Gaspari replied: "I'm not sure what other meds you take, but suffice it to say that 100 mg of Tramadol simply isn't associated with serotonin syndrome. Your symptoms don't resemble serotonin syndrome in the least. Serotonin syndrome is a serious considtion, but I have a distinct suspicion that all your symptoms were adverse effects to the tramadol (not life threatening). Tramadol may just not be a great choice of analgesic for your, but the likelihood of this representing serotonin syndrome is essentially zero."

Serotonin Syndrome? Any info would be great....? 4 weeks ago my doctor put me on a combination of Cymbalta (SNRI)60mg and tramadol 100mg. After becoming "sicker" I stopped both on my own. My doctor attributed my symptoms of feeling worse to worsening depression and fibromyalgia. On Tuesday she had me restart and increased both meds to 90mg Cymbalta and 200mg tramadol and encouraged me to give both a chance to work this time. After the increase, I felt worse than ever and I thought I was going to die for 3 days but my doctor again attributed my symptoms to worsening depression and fibromyalgia. Yesterday, I insisted she switch my meds and she agreed to switch me to Pristiqu another SNRI and told me to continue with the tramadol 200mg. Last night I was reading the info sheet that came with the new med (Pristiqu). It said that Pristiqu or any SNRI (Cymbalta) should NOT be taken with tramadol due to a risk for developing serotonin syndrome. I decided to only take the Pristiqu until I could talk to my dr on Monday. I feel a little better today but not well or perfect. I researched serotonin syndrome on the web today and it sounds quite serious. I had every symptom of serotonin syndrome, except for coma. If I only take the Pristiqu will I be OK till Monday or should I stop all meds? Should I go to an Urgent Care or ER or will I be ok till Monday when I can speak with my doctor?

S P replied: "First, it takes MONTHS for drugs to work. So being on it for a few days will make you feel worse. Second, nothing is wrong with you. You will be fine until monday."

justmeinthisworld replied: "it takes WEEKS (about 3) to achieve the full level of the meds--it may take longer to actually stabilize and feel teh effects- don't stop both--I woudl just stop the tramdol as that mainly works on teh serotonin.. if you stop your meds suddenly--it may caus you to go into withdrawal---you need to taper off.. the doc and pharmacist shoudl have picked up on thsi it is possibel to take both--but usually in low doses of each call the pharmacy and/or doc before doing this---insist the doc think about serotonin syndrome"

Fibrant woman replied: "You probably will be ok until you can see your Dr. Or you can call his office and ask. I have been on Pristiq for 6weeks, it takes several weeks before you start to feel results. I too was taking tramadol but quit using it once I started on the Pristiq. Try for more information. Good luck and better health to you."

how dangerous is it to take tramadol and an ssri? I know there is a risk for serotonin syndrome, but my doctor said it was fairly low. I am in a lot of pain but don't want to use a narcotic. yes.. I forgot how stupid medications were... I mean, how silly were we when we gave my MINISTER grandfather medication to make him feel better!

Angela M replied: "Call the pharmacy and ask. Their advice is free."

nutsterrt replied: "Tramadol is an odd animal and is not a traditional narcotic. It works more by modulating of serotonin and noradrenaline than having an affinity for mu-opioid receptors, so it's more of a pseudo-narcotic. Serotonin syndrome will be your greatest concern and, as your doctor said, as long as you don't go crazy with the Tramadol, it should be relatively mild. If you're doctor is aware of your taking it, it's probably an effective option."

ashenfog replied: "First off, I wonder how the risk of serotonin syndrome is "low" when medicine has no way of measuring your serotonin levels to begin with (you may have had more than enough even BEFORE you made it higher with anti-depressant medication, see? - and where might that put you even now?). Secondly, I would strongly encourage you to find out what horrors toxic serotonin elevation can wreak upon the human body before you decide whether or not any benefit AT ALL is worth the potential perils of being a lab rat for what, under the most CONTROLLED of circumstances, would have to be considered a chemical cocktail. Lastly, I would urge you to consider finding the educational and spiritual resources necessary to, at the proper time and by the proper method, come off of the pharmaceuticals altogether. All drugs are controlled doses of POISON and should only be used as last-ditch efforts to save life or limb. Drug companies exist to do one thing above all else - make billions of dollars. Do not believe seductive commercials with dreamy background music and florescent butterflies fluttering about - drugs are always detrimental in the end. And the FDA has got the hugest scam in the world going by implying, through the approving of highly selective and misleading research by greedy pharmaceutical companies, that these drugs have been made available to the public because they are safe. Big money corrupted the FDA's relationship to the drug juggernauts many years ago and unsuspecting Americans have been paying the physiological prices for that ever since. Read Kevin Trudeau's NATURAL CURES "They" Don't Want You To Know About. And remember the saying, "Strong and free - no drugs for me!" God bless."

Mathieu replied: "Partly depends on the dosage. 40 mg of Paxil and a total daily dose of 400 mg of Tramadol is not the best. Like another said, Tramadol does have opiate (narcotic) activity. And Tramadol is technically and chemically an antidepressant (and SNRI). When I was younger I was prescribed Lexapro (which was hell for me) and my doctor refused to keep me on the Tramadol for chronic pain so I started Vicodin, which I had used many times before. I also had a doctor who was fine with the combination of Tramadol and an SSRI and the pharmacist said the risk was low. Oh if you have epilepsy or have ever had a seizure it is not smart to take the two drugs. Tramadol is at or near the top of the list of drugs that will make people seize (normally when people take too much). But if you have no history and take it as prescribed then the risk is very tiny."

AbeLincolnParty replied: "tramadol is not a good narcotic pain medication, it has less than 1/100 the binding to the mu narcotic receptor while at the same time has seizure risks (especially with alcohol). Marketing has more to do with it being prescribed and abused than actual pain relief or narcotic effects. Tramadol is an reuptake inhibitor and serotonin syndrome risk is increased with another SSRI. Serotonin syndrom risks might change over time, some people accumulate the SSRI drugs slowly and it might take a month before plama levels reach a steady state. SSRI drugs are over prescribed, most people don't need them anyway."

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